These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (2024)

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (1)

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Let’s face it: There’s nothing worse than an itch you can’t scratch or soothe. Whether your itchiness is from a bug bite, a sweat-induced eczema flare-up, or maybe even a surprise encounter with poison ivy while weeding, it’s crucial to have the best anti-itch cream on hand that actually works—and fast.

Luckily, there are many over-the-counter anti-itch creams that can help alleviate itchiness to provide calm, soothing relief. Besides bug bites, eczema, and skin rashes, you can use anti-itch creams to relieve itchiness from psoriasis, seborrheic dermatitis, sunburns, allergic reactions, and more, explains Anar Mikailov, M.D., F.A.A.D. founder of Skintensive. Although you may immediately think of hydrocortisone cream, it’s actually not the only option.

“Anti-itch creams often contain an ingredient called pramoxine hydrochloride that acts as a topical anesthetic, minimizing the sensation of itching or pain,” explains Rebecca Marcus, M.D., board-certified dermatologist and founder of Maei MD. “Topical steroids such as hydrocortisone decrease itch by decreasing inflammation.”

Meet the experts: Anar Mikailov, M.D., F.A.A.D., founder of Skintensive; Merry Thornton, PA-C, board-certified physician assistant and founder of Element Medical Aesthetics; and Rebecca Marcus, M.D., board-certified dermatologist and founder of Maei M.D.

Other ingredients you may want to look in a good anti-itch cream include menthol, which can help by stimulating sensations of warmth and cooling that “detracts from the itch sensation,” says Dr. Marcus. Even coconut oil, Dr. Mikailov adds, has anti-itch properties because it’s moisturizing, and dryness can cause your skin to crawl.

If you’re unsure exactly what to look for, don’t worry: We’ve done the work for you and rounded up all the best anti-itch creams out there, as recommended by doctors and dermatologists, to help you find soothing, fast-acting relief.

Our top picks

Ready to soothe your itches? Ahead, find top-rated creams, gels, ointments, and lotions that experts recommend to beat the itch.

1

Best Overall Anti-Itch Cream

CeraVe Itch Relief Moisturizing Cream

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (8)

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (9)

Pros
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (10)Contains moisturizing ceramides
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (11)Creamy, non-greasy formula
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (12)Large jar
Cons
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (13)Tub packaging isn’t the most sanitary

Both Dr. Mikailov and Dr. Marcus recommend this tried-and-true pick. CeraVe is always a go-to brand for derms, and this cream is no exception. “It contains pramoxine hydrochloride, which works within a few minutes to soothe itching,” explains Dr. Marcus. “It also contains ceramides to help reinforce the skin barrier and maintain the skin’s first line of defense.” Plus, it earns a seal of approval from the National Eczema Association and is marketed for use on everything from sunburn to bug bites.

“I have been battling itchy skin for a few years and have tried many products—none of which worked. This is hands down the best product I have tried,” raved one Amazon reviewer. “It truly does stop the itching almost immediately. I only need to apply it in the morning and it lasts all day. Highly recommend!”

ConsistencyCream
Active ingredients1% pramoxine hydrochloride, hyaluronic acid
Size12 oz

2

Best Hydrocortisone Anti-Itch Cream

Cortizone 10 Intensive Healing Creme

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (14)

Pros
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (15)Fast-acting
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (16)Gentle on skin
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (17)Comes in a pack of 3
Cons
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (18)Consistent use is not encouraged

Looking for a reliable hydrocortisone cream? Dr. Marcus recommends this one because it’s a decent-strength topical steroid for over-the-counter that reduces inflammation caused by sunburn and other skin irritations like poison ivy or bug bites. However, Dr. Mikailov adds that it’s important to use a steroid cream for no longer than two weeks consistently to avoid withdrawal or resistance, which can worsen irritation.

“This is the original stuff! It works the BEST at stopping those maddening itches,” said one Amazon customer. “I’ve tried others with aloe but this is the absolute best for my dry skin itches. It stops me from scratching until I bleed.”

ConsistencyCream
Active ingredientsHydrocortisone
Size2 oz

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3

Best Anti-Itch Cream for Psoriasis

CeraVe Psoriasis Moisturizing Cream

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (19)

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (20)

Pros
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (21)Calming ingredients
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (22)Approved by the National Psoriasis Foundation
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (23)Fragrance-free, non-comedogenic, and allergy-tested
Cons
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (24)Some reviewers note issues with the pump design

Approved by the National Psoriasis Foundation, this top-rated CeraVe Cream is specifically formulated to moisturize and exfoliate dry, itchy, and scaly skin that’s associated with psoriasis. It contains 2% salicylic acid and lactic acid for gentle exfoliation, as well as skin-soothing niacinamide, ultra-moisturizing urea, and three essential ceramides to help restore the skin’s natural barrier. The formula is fragrance-free, non-comedogenic, and allergy-tested—however, you should make sure not to skip sunscreen when using this product, as it contains alpha hydroxy acid, which can increase your skin’s sensitivity to sunburn.

“This is the best product I have found for treatment of severe psoriasis, and I have tried many. To me, it is a miracle in a jar,” wrote one reviewer. “It not only softened my skin but also worked on the scales...But the best result by far is that the itch is gone.”

ConsistencyCream
Active Ingredients2% salicylic acid
Size8 oz

4

Best Anti-Itch Cream for Cooling Relief

Gold Bond Maximum Strength Medicated Anti-Itch Cream

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (25)

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (26)

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Pros
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (27)Contains cooling menthol
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (28)Contains soothing aloe and vitamin E
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (29)Affordable
Cons
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (30)Small amount

Great for treating insect bites, poison ivy rashes, and even minor cuts, scrapes, and burns, Gold Bond’s anti-itch cream not only contains pramoxine hydrochloride to help relieve itching but also menthol—an ingredient that Dr. Marcus recommends for its cooling and warming sensation that detracts from itchiness. The fast-acting, steroid-free formula also contains aloe and vitamin E, which further help soothe irritated skin.

Reviewers say the cream truly works to relieve itchiness quickly and effectively, with one Amazon customer calling it “the best!” It “instantly takes away the itch and cools your skin. No lingering smell, no mess. Love this stuff,” they continued.

ConsistencyCream
Active Ingredients1% menthol, 1% pramoxine hydrochloride
Size1 oz

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5

Best Anti-Itch Cream for Bug Bites

Benadryl Extra Strength Anti-Itch Topical Gel

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (31)

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (32)

Now 45% Off

Pros
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (33)Relieves itchiness from bug bites and other outdoor itches
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (34)Cooling sensation on skin
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (35)Affordable
Cons
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (36)Some reviewers report it leaves a glue-like residue

Merry Thornton, PA-C, board-certified physician assistant and founder of Element Medical Aesthetics, prefers this anti-itch gel. Thornton recommends the ingredient diphenhydramine for itchiness caused by insect bites and sunburn. This gel can also calm skin irritation from poison ivy, scrapes, rashes, and other outdoor itches.

It’s racked up over 34,000 ratings on Amazon, with one reviewer writing: “This stuff is a God-send! It usually starts working within two to three minutes after I put it on, it’s lightweight, and it doesn’t leave a sticky or oily residue after it absorbs.”

ConsistencyGel
Active ingredients2% diphenhydramine hydrochloride
Size3.5 oz

6

Best Soothing Anti-Itch Cream

Aveeno Maximum Strength 1% Hydrocortisone Anti-Itch Cream

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (37)

Pros
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (38)Soothing and anti-inflammatory
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (39)Fast-acting
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (40)Calming ingredients
Cons
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (41)Not ideal for eczema

Like Cortisone 10, this maximum-strength cream contains anti-inflammatory hydrocortisone, so it should be used in no more than two-week bouts. However, it provides fast-acting relief for rashes like poison oak, bug bites, and sunburn, and shoppers love the added benefits of soothing colloidal oatmeal, aloe, and vitamin E.

“This is from someone who is severely allergic to insect and spider bites. We’re talking large, red welts here that itch mercilessly. A small amount works well. Penetrates the skin quickly. Gets to work fast. No obnoxious smell,” one reviewer said. Plus, one tube lasts a long time.

ConsistencyCream
Active ingredients1% hydrocortisone
Size2 oz

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Pros
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (44)Steroid-free
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (45)Fast-acting
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (46)National Eczema Association-approved
Cons
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (47)Some reviewers say the consistency is too watery

This ointment, recommended by Dr. Mikailov, contains aluminum acetate, which acts as an astringent to relieve itch. It doesn’t contain steroids, which means it’s safe to use as often as needed—making it a great alternative to hydrocortisone creams which are not recommended to use long-term. The gel is easily applied and marketed for use on bug bites, poison oak or sumac, and even athlete’s foot—plus, it’s also approved by the National Eczema Association.

“Wow, this stuff has made a big difference! I have continuous itching along a nerve in my back, and this actually ‘calms’ it for hours at a time,” an Amazon reviewer wrote. “So far, it’s the best I’ve used, and I love that there are no steroids.”

ConsistencyGel
Active ingredients0.2% aluminum acetate
Size2 oz

8

Best Anti-Itch Cream for Sensitive Skin

Sarna Sensitive Anti-Itch Lotion

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (48)

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (49)

Now 12% Off

Pros
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (50)Gentle formula that’s suitable for sensitive skin
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (51)National Eczema Association-approved
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (52)Steroid-free
Cons
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (53)Some reviewers note issues with the pump design

Sarna’s anti-itch lotion contains pramoxine hydrochloride to help with itching and is fragrance-free and moisturizing, says Dr. Marcus. “Hydration is key for those with dry, sensitive skin, and for those with eczema,” she says. In fact, this cream is designed specifically for sensitive skin, with a gentle formula that doesn’t contain potentially-irritating steroids, parabens, or fragrances—not to mention, it also has a seal of approval from the National Eczema Association.

One Amazon reviewer calls it a “lifesaver,” writing: “I have super sensitive skin and breakout in hives and eczema. I’ve never heard of this lotion before but it was recommended by my dermatologist. It is amazing. It’s unscented and your skin feels so good afterwards...I love it and it has helped me so much!”

ConsistencyLotion
Active ingredients1% pramoxine hydrochloride
Size7.5 oz

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9

Best Anti-Itch Cream for Eczema

Eucerin Eczema Relief Cream

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (54)

Pros
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (55)Calming ingredients
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (56)Contains soothing colloidal oatmeal
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (57)Affordable
Cons
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (58)Some reviewers say it doesn’t manage severe flare-ups

“Eucerin Eczema Relief contains colloidal oatmeal to calm inflamed skin, as well as ceramides-3 and licochalone to soothe dry, itchy skin,” explains Dr. Marcus. Specifically formulated to soothe eczema, this soothing cream is free of fragrances, dyes, and steroids. It’s even safe for use on children and babies, too: In a clinical study, daily use of it saw four out of five children remain eczema flare-free for six months, according to the brand.

“I have tried every single product for eczema and none of them ever worked until I tried this one...I’ve seen the best results ever,” said one Amazon shopper. “I’ve personally have really bad eczema on my hands and around my lips and when I tell you, I feel like a brand new person, I do!”

ConsistencyCream
Active ingredients1% colloidal oatmeal
Size8 oz

10

Best Anti-Itch Cream for Dry Skin

Skintensive Body Butter with Ceramides and Sea Buckthorn Berry

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (59)

Pros
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (60)Moisturizing
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (61)Certified organic ingredients
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (62)Fast-absorbing and non-greasy
Cons
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (63)Pricey

If you’re looking to soothe a full-body itch that seems angriest after hopping out of a hot shower, a good, moisturizing body butter should do the trick. Soothing ceramides and cocount oil in this one from Dr. Mikailov’s brand help restore the skin’s barrier and therefore eliminate skin crawling or creeping of any kind. Vitamins C and E in sea buckthorn oil give the skin an added boost of protective antioxidants.

“This helps me with my itching and scaling areas quite a bit...Absorbs quickly without leaving a greasy feeling behind,” said one reviewer.

ConsistencyBalm
Active ingredientsCeramides, vitamin C, vitamin E
Size8 oz

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11

Best Value Anti-Itch Cream

Curel Itch Defense Calming Body Lotion

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (64)

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (65)

Pros
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (66)Gentle, soothing formula
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (67)20-ounce bottle
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (68)Affordable
Cons
  • These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (69)Some users require stronger itch relief

Safe for use from head to toe, this affordable body lotion has been a saving grace for users’ dry skin, allergic reactions, eczema, and more. It contains an advanced ceramide complex, pro-vitamin B5, and shea butter, making it gentle enough for everyday use. And at just $11, you get a long-lasting 20-ounce bottle.

“This lotion is amazing! I’m so happy I finally found something that works,” an Amazon customer raved. “From just one day of using it, my eczema has already cleared up significantly.”

ConsistencyLotion
Active IngredientsCeramides
Size20 oz

How to choose (and use) the best anti-itch cream

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (70)

✔️ Look for active ingredients pramoxine hydrochloride, camphor, menthol, and colloidal oatmeal: These ingredients specifically target the itch or create a sensation that distracts from it.

✔️ Tread lightly with hydrocortisone: “Sometimes over-the-counter, low-strength hydrocortisone can help with certain causes of itch, but it is important to limit use to 14 days,” says Dr. Mikailov. That’s because steroid cream withdrawal or resistance can develop.

✔️ Know that anti-itch creams offer temporary relief: They are not a cure. If your skin irritation worsens quickly, does not resolve within two to three days, or comes with other systemic symptoms, both Dr. Mikailov and Dr. Marcus advise seeking professional help. “Also, if you have persistent itching and no identifiable rash, it’s a good idea to have a doctor evaluate you as generalized itching can be caused by medical conditions including anemia, thyroid disorders, and lymphoma,” adds Dr. Marcus.

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How does anti-itch cream work?

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (71)

Recent research shows that the chemical ingredients in anti-itch creams work like a key and lock system. The anti-itch chemical is the “key” that reacts with cells’ receptor proteins, which is the “lock.” One of these receptors is on itch-sensing neurons, so when the chemical opens the cell, a chain reaction releases histamines, which causes itching. Anti-itch creams that have antihistamines reduce this response and block the histamines from forming to stop itchiness.

What ingredients are best at combating itchiness?

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (72)

The best ingredients at combating itchiness depend on why your skin is itchy in the first place. Regular dry skin can be treated with menthol, calamine, and hydrocortisone, which will help relieve itching.

“For sunburn, insect bites, and minor skin irritation, I like Cerave Itch Relief, which has pramoxine, or Benadryl Extra Strength Itch Gel which has diphenhydramine,” Thornton says.

If your itchiness is due to eczema or poison ivy, over-the-counter ingredients may not cut it. Instead, Thornton suggests using a potent prescription topical steroid. Topical corticosteroids used to treat eczema have multiple levels of potency, each with different ingredients. Low-potency corticosteroids have hydrocortisone and prednisolone, moderate-potency has prednicarbate, methylprednisolone, and triamcinolone; and high-potency corticosteroids have betamethasone and mometasone.

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Why is my skin so itchy?

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (73)

Again, it depends on the cause. Dry skin makes your skin feel itchy, according to the Mayo Clinic. Eczema, sunburn, low outdoor temperature, lack of moisturizing, smoking, and even taking long-hot showers are just some of the conditions and behaviors that cause dry, itchy skin.

When your skin is more itchy than normal or you cannot find relief with lotions, you may be experiencing an allergic reaction. “Itchy skin can be due to a high level of histamines from allergens such as dust, mold, dander, food, or medications,” Thornton says. “This is also seen with bee stings, insect bites, and hives.”

Thornton also says viruses that affect the nerves can cause itching, such as shingles and herpes simplex.

When to see a doctor

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (74)

Itchy skin isn’t always a cause for concern, and a bit of moisturization and anti-itch cream can help quickly. However, when you’re slathering on creams and lotions but you can’t stop scratching, it might be time to see a doctor. “If the itch is not improving after two weeks of using the anti-itch cream, you should see a doctor to make sure of the diagnosis and appropriate treatment,” Thornton says.

“If the skin looks infected (red, hot to touch, oozing), you should see a doctor,” Thornton explais. “Also, if the itch is not improving after two weeks of using the anti-itch cream, you should see a doctor to make sure of the diagnosis and appropriate treatment.”

Seeing a doctor can help you identify and treat the root of the problem, especially if the itching is masking a more serious health problem. “Shingles can start out looking like a bug bite, but can become serious without oral antiviral treatment,” Thornton says. “Also, eczema and poison ivy can become severe without systemic prescribed medications.”

When the itching is severe, long-lasting, or consistent, a doctor can provide long-term treatment plans to help your skin feel calmer and less itchy.

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How we chose the best anti itch creams

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (75)

We asked Anar Mikailov, M.D., F.A.A.D., founder of Skintensive; Merry Thornton, PA-C, board-certified physician assistant and founder of Element Medical Aesthetics; and Rebecca Marcus, M.D., board-certified dermatologist and founder of Maei M.D., for their recommendations. We researched products individually and explored hundreds of customer reviews to include some of the market’s best-sellers. We also conducted our own research.

Why trust us?

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (76)

For more than 70 years, Prevention has been a leading provider of trustworthy health information, empowering readers with practical strategies to improve their physical, mental, and emotional well-being. Our editors interview medical experts to help guide our health-focused product selections. Additionally, Prevention also examines hundreds of reviews—and often conducts personal testing done by our staff—to help you make informed decisions.

These 11 Anti-Itch Creams Will Soothe All Types of Irritation, According to Experts (2024)
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